Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.6K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.6K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

638
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
638
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

1.8K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.8K
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

708
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
708

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Real-world effectiveness of anti-interleukin-23 antibodies in chronic plaque-type psoriasis of patients from the Austrian Psoriasis Registry (PsoRA).

Scientific reports·2024
Same author

Real-world effectiveness of anti-interleukin-23 antibodies in chronic plaque-type psoriasis of patients from the Austrian Psoriasis Registry (PsoRA).

Scientific reports·2022
Same author

PROSPECT guideline for total hip arthroplasty: a systematic review and procedure-specific postoperative pain management recommendations.

Anaesthesia·2021
Same author

Regional anaesthesia in patients with diabetes.

Anaesthesia·2021
Same author

Biologic drug survival rates in the era of anti-interleukin-17 antibodies: a time-period-adjusted registry analysis.

The British journal of dermatology·2020
Same author

Demyelinating Charcot-Marie-Tooth neuropathy associated with FBLN5 mutations.

European journal of neurology·2020

Related Experiment Video

Updated: Mar 24, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
07:58

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

270

Diabetic neuropathy increases stimulation threshold during popliteal sciatic nerve block.

S Heschl1, B Hallmann1, T Zilke1

  • 1Department of Anaesthesiology and Intensive Care Medicine, Medical University of Graz, Auenbruggerplatz 29/I, Graz 8036, Austria.

British Journal of Anaesthesia
|March 20, 2016
PubMed
Summary

Peripheral nerve stimulation for regional anesthesia requires higher currents in diabetic patients, especially those with sensory deficits. Standard stimulation thresholds may not reliably indicate needle proximity in these individuals.

Keywords:
diabetic neuropathiesnerve blockperoneal nervetibial nerve

More Related Videos

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
10:27

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

Published on: October 20, 2017

7.9K
Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

4.2K

Related Experiment Videos

Last Updated: Mar 24, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
07:58

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

270
An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
10:27

An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

Published on: October 20, 2017

7.9K
Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

4.2K

Area of Science:

  • Anesthesiology
  • Neurology
  • Medical Devices

Background:

  • Peripheral nerve stimulation is crucial for nerve localization in regional anesthesia.
  • Current recommendations (0.3-0.5 mA) may not consistently elicit motor responses, particularly in diabetic neuropathy.
  • Diabetic neuropathy might further complicate accurate nerve localization via stimulation.

Purpose of the Study:

  • To compare nerve stimulation thresholds in diabetic and non-diabetic patients undergoing popliteal sciatic nerve blocks.
  • To investigate the influence of diabetic neuropathy on the current required for motor response.
  • To evaluate the reliability of standard stimulation currents for determining needle-nerve proximity in diabetic patients.

Main Methods:

  • Ultrasound-guided popliteal sciatic nerve block was performed.
  • Stimulation current thresholds for tibial and common peroneal nerves were measured.
  • Neurological exams, electroneurography, and post-hoc ultrasound imaging were utilized.

Main Results:

  • Average stimulation currents did not significantly differ between diabetic and non-diabetic groups.
  • Diminished pressure or pain sensation correlated with higher stimulation thresholds.
  • Slowed ulnar nerve conduction velocity predicted elevated stimulation current.
  • A higher proportion of diabetic patients required >0.5 mA or >2 mA for motor response, even with confirmed needle proximity.

Conclusions:

  • Standard stimulation thresholds (0.3-0.5 mA) may be insufficient for reliable needle-nerve contact assessment in popliteal sciatic nerve blocks.
  • Diabetic neuropathy, particularly with sensory deficits, may necessitate higher stimulation currents.
  • These findings highlight the need for adjusted stimulation current parameters in diabetic patients.