Family functioning and adolescent alcohol use: A moderated mediation analysis
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Updated: Mar 24, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
Published on: December 14, 2014
Christine McCauley Ohannessian1, Kaitlin M Flannery2, Emily Simpson3
1Children's Center for Community Research, Connecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA; Department of Pediatrics, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06032, USA; Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06032, USA.
Abstract:
The primary goals of this longitudinal study were to examine the relationship between family functioning and adolescent alcohol use and to examine whether depressed mood mediates this relationship. An additional goal was to explore whether these relations were moderated by gender. The sample included 1031 high school students from the Mid-Atlantic United States. Participants completed surveys in school during the spring of 2007, 2008, and 2009. Path analysis results indicated that family functioning predicted alcohol use for girls. Moreover, depressed mood mediated this relationship. None of the direct paths between family functioning and adolescent alcohol use were significant for boys. However, similar to girls, depressed mood negatively predicted alcohol use for boys. Taken together, the findings highlight the need for prevention programs targeting adolescent substance use to consider gender-specific trajectories.
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