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Action Potential

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...

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Related Experiment Video

Updated: Mar 24, 2026

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

Exploring human epileptic activity at the single-neuron level.

¹Center for Study of Movement, Cognition and Mobility, Department of Neurology and Functional Neurosurgery Unit, Tel Aviv Sourasky Medical Center, Tel-Aviv 6423906, Israel; Department of Neurology and Neurosurgery, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.

Epilepsy & Behavior : E&B

|March 20, 2016

Summary

This summary is machine-generated.

High-resolution microelectrode technology reveals that seizure-related neuronal activity can precede clinical seizure onset. This advanced monitoring offers new insights into epilepsy mechanisms and potential seizure prediction.

Keywords:

Epilepsy Interictal activity Microelectrode recordings Neurophysiology Postictal state Seizure prediction Single neurons

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Last Updated: Mar 24, 2026

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Area of Science:

Neuroscience
Epileptology
Biomedical Engineering

Background:

Current epilepsy seizure focus localization relies on electroencephalogram (EEG) monitoring.
Technological advancements now permit simultaneous exploration of hundreds of single human neurons.
This enables a deeper understanding of epilepsy at the neuronal level.

Purpose of the Study:

To review the application of microelectrode technology in epilepsy research.
To explore novel insights into the dynamics of epileptic activity at the single-neuron level.
To discuss the potential of this technology for improved seizure localization and prediction.

Main Methods:

Description of microelectrode technology and implantation setup in epilepsy patients.
Analysis of simultaneous single-neuron recordings before, during, and after seizures.
Investigation of neuronal firing patterns and interactions in the seizure-onset zone and penumbra.

Main Results:

Seizure-related neuronal activity can be detected minutes before EEG-defined seizure onset.
Neuronal interactions during seizures exhibit complex and heterogeneous dynamics.
Distinct firing pattern changes correlate with cell loss in the seizure-onset zone, while neurons in the penumbra maintain stereotypy.

Conclusions:

Extracellular electrical activity recording offers a better understanding of epilepsy mechanisms.
This technology holds promise for more accurate seizure focus localization.
Future applications may include predicting seizures for automatic therapeutic interventions.