Related Experiment Video
Updated: Mar 24, 2026
07:36
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
7.9K
CD4+CD25+ regulatory T cells in tumor immunity
Xin Chen1, Yong Du2, XiuQing Lin1
1Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
International Immunopharmacology
|March 20, 2016
Summary
Regulatory T cells (Tregs) are crucial for immune balance and preventing autoimmunity. In cancer, Tregs suppress anti-tumor immunity, highlighting their role in disease progression and potential therapeutic targets.
Area of Science:
- Immunology
- Oncology
Background:
- Regulatory T cells (Tregs) are vital for peripheral tolerance and preventing autoimmune and chronic inflammatory diseases.
- Tregs are characterized by CD4, CD25 expression, and the transcription factor FoxP3, with IL-10, IL-35, and TGF-β mediating their function.
- Elevated Treg numbers in cancer patients correlate with poor prognosis and reduced survival rates.
Purpose of the Study:
- To review the cellular and molecular mechanisms governing Treg differentiation and function in the context of tumor immunity.
- To explore the role of Tregs in establishing immune tolerance towards tumors and suppressing anti-tumor responses.
- To discuss the potential of Treg depletion or blockade as an anti-cancer therapeutic strategy.
Main Methods:
- Literature review of studies on Treg differentiation and function.
- Analysis of research on Treg involvement in tumor-associated antigen tolerance and anti-tumor immunity suppression.
- Examination of evidence linking Treg frequency to cancer prognosis and survival.
Main Results:
- Tregs are key mediators of immune tolerance in tumors, suppressing cytotoxic T-cell responses.
- Increased Treg frequencies in cancer are associated with poorer patient outcomes.
- Depleting Tregs or blocking their inhibitory functions can enhance anti-tumor immunity.
Conclusions:
- Tregs play a significant role in immune evasion by tumors.
- Targeting Tregs presents a promising avenue for improving cancer immunotherapy.
- Understanding Treg mechanisms is critical for developing effective anti-cancer strategies.
More Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
01:24T Cell Types and Functions
3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
01:27Cytotoxic T Cells-mediated Immune Response
7.9K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.9K
02:17The Tumor Microenvironment
8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
01:22T Cell Activation and Clonal Selection
17.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
17.2K