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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
106

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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Bioengineered protein-based nanocage for drug delivery.

Eun Jung Lee1, Na Kyeong Lee2, In-San Kim3

  • 1Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.

Advanced Drug Delivery Reviews
|March 21, 2016
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Protein nanocages offer precise control for biological processes and are promising for drug delivery. This review covers their engineering, drug-loading, and therapeutic applications.

Keywords:
BioengineeringCancer therapyDrug deliveryFunctionalizationProtein-based nanocage

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Area of Science:

  • Biochemistry and Structural Biology
  • Nanotechnology and Biomaterials
  • Therapeutic Drug Delivery Systems

Background:

  • Multimeric proteins form cage-like structures, providing spatial control and compartmentalization in biological systems.
  • Protein-based nanocages exhibit ideal symmetry and physical properties, making them attractive for biomedical applications.
  • Their potential as drug delivery carriers is a significant area of research interest.

Purpose of the Study:

  • To review existing protein-based nanocages utilized in therapeutics.
  • To outline drug-loading mechanisms and bioengineering strategies for these nanocages.
  • To present an outlook on future applications, including de novo and in silico design.

Main Methods:

  • Review of current literature on protein-based nanocages for therapeutic purposes.
  • Analysis of genetic and chemical functionalization techniques for bioengineering.
  • Critical evaluation of in vitro and in vivo studies of nanocage-based drug delivery.

Main Results:

  • Various protein nanocage types are suitable for therapeutic applications.
  • Genetic and chemical modifications enable tailored drug-loading and delivery.
  • Recent advances show efficacy in both in vitro and in vivo preclinical models.

Conclusions:

  • Protein nanocages are versatile platforms for advanced drug delivery.
  • Engineering strategies are crucial for optimizing their therapeutic potential.
  • Future research directions include computational design and clinical translation.