Related Experiment Video
Updated: Mar 24, 2026
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Mucosal-associated invariant T cells in clinical diseases
Rangsima Reantragoon1, Norasate Boonpattanaporn, Alexandra Jane Corbett
1Immunology Division, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Unlabelled:
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial infection via vitamin metabolites. The discovery of MAIT cells in the past two decades and the recent discovery of MR1 ligands has opened a new field and potential area for cellular immunotherapy using these unique cells. Their evolutionary conservation in mammals underscore their biological role in the host. In the past two years, we have been involved in the generation of MR1 tetramers as a tool for identification of these cells. Many groups have studied the role of these cells in clinical diseases.
Objective:
Here, we provide an up-to-date comprehensive review of clinical disease that have been studied with regards to MAIT cells.
Results:
Original articles and review articles under the topic of MAIT cells and their relation to clinical diseases, both in human and animal models were included in the review.
Conclusion:
MAIT cells are potential candidates for future cellular immunotherapy. However, more understanding of the biological role of MAIT cells need to be elucidated first.
More Related Videos
Related Concept Videos
01:24T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:26Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...
01:22T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...