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Agnieszka Szymańska-Michalak1, Dariusz Wawrzyniak1, Grzegorz Framski1

  • 1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznań, Poland.

European Journal of Medicinal Chemistry
|March 21, 2016
PubMed

Keywords:
5-fluoro-2′-deoxyuridineAnticancerDouble barrelledGlioblastoma multiformeMulti decoratedNucleoside analogues

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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