MRI findings in eastern equine encephalitis: the "parenthesis" sign
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Updated: Mar 24, 2026

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Published on: September 20, 2024
Joshua P Nickerson1, Suma Kannabiran1, Heather N Burbank1
1Department of Radiology, University of Vermont Medical Center, 111 Colchester Avenue, Burlington VT 05401, USA.
Abstract:
Two patients with eastern equine encephalitis (EEE) presented to a tertiary referral center. Both subjects' brain magnetic resonance imaging showed T2/FLAIR (fluid-attenuated inversion recovery) hyperintensities including linear areas of hyperintensity in the external and internal capsules with sparing of the lentiform nuclei. Single case reports of imaging findings in EEE exist with nonspecific patterns of abnormality. We propose that this "( ) parentheses sign" on T2 or FLAIR imaging may distinguish EEE from other processes.
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