Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

820
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
820
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
Actuarial Approach01:20

Actuarial Approach

358
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
358
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

709
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
709
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

15.4K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.4K
Cancer02:18

Cancer

55.5K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Premalignant lesions of the oral cavity: a narrative review of factors and mechanisms of transformation into cancer.

International journal of oral and maxillofacial surgery·2024
Same author

Genetic Features of Tongue Cancer Recurrence in Young Adults.

Bulletin of experimental biology and medicine·2024
Same author

Molecular subtype conversion in CTCs as indicator of treatment adequacy associated with metastasis-free survival in breast cancer.

Scientific reports·2022
Same author

Early-onset oral cancer as a clinical entity: aetiology and pathogenesis.

International journal of oral and maxillofacial surgery·2022
Same author

Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.

Molecular biology reports·2021
Same author

Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx.

Bulletin of experimental biology and medicine·2020

Related Experiment Video

Updated: Mar 24, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.4K

[Cancer mortality in the Altai Republic].

I N Odintsova, L F Pisareva, A V Khryapenkov

    Voprosy Onkologii
    |March 22, 2016
    PubMed
    Summary

    The Altai Republic shows the lowest cancer mortality in Siberia, with males experiencing rates 1.9 times higher than females. Urban populations face increased cancer incidence and mortality risks compared to rural areas.

    Area of Science:

    • Oncology
    • Public Health
    • Epidemiology

    Context:

    • The Altai Republic exhibits the lowest cancer mortality rates within the Siberian Federal District.
    • Significant disparities exist in cancer mortality between males and females, with males facing higher rates.
    • Cancer mortality rates demonstrated stability within a defined confidence interval between 2003 and 2012.

    Purpose:

    • To analyze cancer mortality trends and risk factors in the Altai Republic.
    • To compare cancer incidence and mortality rates between urban and rural populations.
    • To identify specific cancer types contributing to mortality differences.

    Summary:

    • Male mortality is predominantly linked to respiratory and digestive system tumors, while female mortality involves reproductive and digestive system tumors.

    More Related Videos

    Establishing a Competing Risk Regression Nomogram Model for Survival Data
    04:57

    Establishing a Competing Risk Regression Nomogram Model for Survival Data

    Published on: October 23, 2020

    11.0K
    Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
    09:03

    Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

    Published on: January 26, 2024

    778

    Related Experiment Videos

    Last Updated: Mar 24, 2026

    Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
    07:47

    Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

    Published on: September 15, 2023

    2.4K
    Establishing a Competing Risk Regression Nomogram Model for Survival Data
    04:57

    Establishing a Competing Risk Regression Nomogram Model for Survival Data

    Published on: October 23, 2020

    11.0K
    Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
    09:03

    Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

    Published on: January 26, 2024

    778
  • Age-standardized cancer incidence rates are significantly higher in urban residents compared to their rural counterparts.
  • Urban males exhibit higher mortality from lung, liver, and kidney cancers; urban females show increased mortality from breast, stomach, and rectal cancers.

    • Impact:

    • Urban populations in the Altai Republic face a higher overall risk of cancer mortality.
    • Targeted public health interventions are needed to address cancer disparities in urban vs. rural settings.
    • Understanding site-specific cancer mortality patterns is crucial for regional health strategies.