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The long-term risk of recognized and unrecognized myocardial infarction for depression in older men

O Jovanova1, A I Luik1, M J G Leening1

  • 1Department of Epidemiology,Erasmus MC, University Medical Center Rotterdam,Rotterdam,The Netherlands.

Psychological Medicine
|March 22, 2016
PubMed
Abstract

Insights

Recognized myocardial infarction (MI) is linked to higher depressive symptoms, unlike unrecognized MI. This suggests the psychological impact of a known heart attack contributes to depression risk.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • The link between myocardial infarction (MI) and depression is established, but underlying mechanisms and psychological factors remain unclear.
  • Both recognized (RMI) and unrecognized (UMI) myocardial infarctions impact cardiovascular health similarly, yet differ in psychological effects.

Purpose of the Study:

  • To investigate the differential impact of RMI and UMI on the risk of depression.
  • To explore the association of RMI and UMI with depressive symptoms and major depression.

Main Methods:

  • The Rotterdam Study cohort, including 1823 men aged 55 years and older, was followed for depression occurrence.
  • RMI and UMI were identified via electrocardiography and medical history.
  • Associations with mortality, depressive symptoms, and major depression were analyzed.

Main Results:

  • Mortality risk was similar for RMI (aHR 1.71) and UMI (aHR 1.58).
  • Men with RMI showed significantly higher depressive symptom scores (B 1.14).
  • No clear association was found between UMI and depressive symptoms (B 0.55).

Conclusions:

  • The distinct associations of RMI and UMI with depression, compared to mortality, highlight the psychological burden of recognized heart attacks.
  • The psychological impact of experiencing a recognized MI appears to be a significant contributor to the long-term risk of developing depression.
Keywords:
Depressionepidemiologymyocardial infarctionpopulation based

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