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[Sneddon's syndrome. 2 case reports]

A Lazarova1, K Pramatarov, N Kiriakova

  • 1Instituto Científico de Dermatología y Venereología, Academia de Medicina, Sofía, Bulgaria.

Medicina Cutanea Ibero-Latino-Americana
|January 1, 1989
PubMed

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Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.