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PELP1: Structure, biological function and clinical significance

Gangadhara Reddy Sareddy1, Ratna K Vadlamudi1

  • 1Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States.

Gene
|March 22, 2016
PubMed

Insights

Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a key protein involved in cancer. This review summarizes PELP1

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Epigenetics

Background:

  • Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein.
  • PELP1 interacts with transcription factors, nuclear receptors, and chromatin-modifying complexes.
  • Histone modifications and kinase phosphorylation regulate PELP1 function.

Purpose of the Study:

  • To review the biological properties and functions of PELP1.
  • To highlight PELP1's roles in various cellular pathways.
  • To discuss PELP1's significance in cancer and as a therapeutic target.

Main Methods:

  • Literature review of existing studies on PELP1.
  • Analysis of PELP1's interactions with other proteins and complexes.
  • Examination of PELP1's role in cancer signaling and response.

Main Results:

  • PELP1 regulates hormonal signaling, cell cycle, ribosomal biogenesis, and DNA damage response.
  • PELP1 expression is elevated in various cancers.
  • PELP1 deregulation is linked to therapy resistance and poor prognosis in breast cancer.

Conclusions:

  • PELP1 is a crucial regulator in multiple cellular processes.
  • PELP1's aberrant expression and function make it a significant factor in cancer development.
  • PELP1 represents a promising therapeutic target for hormonal cancers.

Keywords:
CoregulatorEstrogen receptorHormonal actionNuclear receptorPELP1Signal transductionTranscriptional activation

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