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Pathologic findings after recession and resection of extraocular muscles in rabbits
Abstract:
A study on the pathologic findings after recession and resection of extraocular muscles in rabbits was performed. Fibrosis of the extraocular muscles increased with time, which showed no difference between the recessed and resected muscles. Inflammation and foreign body reaction decreased with time, which showed no difference between the recessed and resected muscles. Adhesions of extraocular muscles to the sclera were observed from one month after the operation. The resected muscles showed milder adhesion to the sclera than the recessed ones. The operated extraocular muscles showed atrophies at one month, which showed no difference between the recessed and resected muscles. According to our results, when reoperation is needed, fibrosis of the extraocular muscles after recession and resection should be considered when making a decision on the amount of muscle to be recessed and resected.
Insights
Extraocular muscle recession and resection in rabbits led to increased fibrosis and atrophy over time. Resected muscles showed less scleral adhesion than recessed muscles, a key factor for future reoperation decisions.
Area of Science:
- Ophthalmology
- Veterinary Pathology
- Surgical Research
Background:
- Extraocular muscle surgery, including recession and resection, is common in treating strabismus.
- Understanding the long-term pathologic changes following these procedures is crucial for surgical planning and patient outcomes.
Purpose of the Study:
- To investigate and compare the pathologic findings in extraocular muscles after recession and resection surgeries in a rabbit model.
- To evaluate the temporal progression of fibrosis, inflammation, adhesion, and atrophy.
Main Methods:
- Rabbits underwent either extraocular muscle recession or resection.
- Histopathologic analysis was performed at various time points post-surgery.
- Key findings assessed included fibrosis, inflammation, foreign body reaction, scleral adhesion, and muscle atrophy.
Main Results:
- Fibrosis and atrophy of extraocular muscles increased over time, with no significant difference between recession and resection groups.
- Inflammation and foreign body reactions decreased over time, also similar in both groups.
- Scleral adhesions were observed one month post-operation, being less severe in the resected muscles compared to recessed muscles.
Conclusions:
- Both recession and resection result in progressive fibrosis and atrophy of extraocular muscles.
- The degree of scleral adhesion differs between the two techniques, with resection showing milder adhesions.
- These findings are important for surgeons to consider, particularly the potential for fibrosis and adhesion, when planning reoperations.