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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Mar 23, 2026

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
03:35

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Macular Thickness Variability in Primary Open Angle Glaucoma Patients using Optical Coherence Tomography.

Anjali Sharma1, Prakashchand Agarwal1, P Sathyan2

  • 1Assistant Professor, Department of Ophthalmology, People's College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India.

Journal of Current Glaucoma Practice
|March 22, 2016
PubMed
Summary

Primary open-angle glaucoma (POAG) patients showed reduced macular volume and thickness compared to healthy individuals. These optical coherence tomography (OCT) findings aid in glaucoma diagnosis, particularly with disc abnormalities.

Keywords:
GlaucomaMacular thicknessOptical coherence tomography.

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Area of Science:

  • Ophthalmology
  • Medical Imaging

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Accurate diagnostic tools are crucial for early detection and management of POAG.

Purpose of the Study:

  • To compare macular thickness and volume in POAG patients versus healthy controls using optical coherence tomography (OCT).
  • To evaluate the diagnostic utility of macular parameters in POAG.

Main Methods:

  • An observational case-control study involving 124 eyes of POAG patients and 124 eyes of healthy controls.
  • Comprehensive ophthalmic examinations and Humphrey Field Analyzer testing.
  • Macular imaging performed using Stratus OCT to analyze macular thickness (IMT, OMT, CMT) and total macular volume (TMV).

Main Results:

  • POAG patients exhibited significantly decreased total macular volume (TMV), outer macular thickness (OMT), and inner macular thickness (IMT) compared to controls.
  • Central macular thickness (CMT) showed no significant difference between groups.
  • Macular thickness and volume parameters demonstrated potential for glaucoma diagnosis.

Conclusions:

  • Macular thickness parameters, particularly TMV, OMT, and IMT, are significantly altered in POAG.
  • These OCT-derived macular metrics correlate with glaucoma diagnosis and may assist in identifying the disease, especially in cases with disc anomalies.