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20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration
Bin Li1, Daomei Chen1, Wanyi Li2
1Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Pharmacy, School of Chemical Sciences and Technology, Yunnan University, Kunming, Yunnan 650091, P.R. China.
Abstract:
While the anti-tumor actions of ginsenosides from Panax notoginseng are well-studied, the anti-proliferative activity of 20(S)-protopanaxadiol saponins (PDS) in Sanchi ginseng on human ovarian cancer has not been reported, nor has its effect on migration of SKOV3 cells been investigated. In the present study, a wound-healing assay indicated that PDS inhibited the migration of SKOV3 cells, and a Matrigel™ tube formation assay demonstrated the presence of inhibitory tube-structures following treatment with PDS. To date, there are no previous reports on the regulation of osteopontin (OPN), a glycophosphoprotein cytokine frequently expressed in ovarian carcinoma effusions by PDS. A reduction in the expression of OPN following PDS-treatment was observed using immunohistochemical and western blot experiments. These results suggest that PDS may be useful in the search for a potential ovarian cancer treatment.
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