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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Related Experiment Video

Updated: Mar 23, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Giant non-functional parathyroid cyst: A case report.

X U Zhang1, Jun-Hui Yuan2, L U Feng1

  • 1Department of Head, Neck and Thyroid, Affiliated Tumor Hospital, Zhengzhou University, Zhengzhou, Henan 450008, P.R. China.

Oncology Letters
|March 22, 2016
PubMed
Summary

Giant parathyroid cysts (PCs) are rare and benign, sometimes causing compressive symptoms. Diagnosis involves elevated parathyroid hormone (PTH) in cyst fluid, with surgical excision recommended for symptomatic cases.

Keywords:
mediastinal lesionnon-functioningparathyroid cystparathyroid lesionsurgical excision

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Pathology

Background:

  • Giant parathyroid cysts (PCs) are uncommon benign lesions.
  • These cysts can be functional or non-functional, secreting parathyroid hormone (PTH).
  • Compressive symptoms may arise due to the mass effect of large cysts.

Purpose of the Study:

  • To report a rare case of a giant parathyroid cyst.
  • To review the clinical presentation, diagnosis, and management of such cases.
  • To discuss the diagnostic criteria and treatment recommendations for giant PCs.

Main Methods:

  • Case report of a 56-year-old male with a giant PC.
  • Review of clinical data, laboratory tests, and radiographic findings.
  • Analysis of cyst fluid for parathyroid hormone (PTH) levels.
  • Literature review on giant parathyroid cysts.

Main Results:

  • The patient presented with exertional dyspnea and dysphagia.
  • Diagnosis confirmed by elevated PTH in aspirated cyst fluid.
  • Giant PCs can cause significant compressive symptoms.

Conclusions:

  • Giant parathyroid cysts are rare but benign.
  • Diagnosis relies on PTH levels in cyst fluid.
  • Surgical excision is the recommended treatment for symptomatic giant PCs.