Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.8K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.8K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.3K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.3K
Chemical Synapses01:26

Chemical Synapses

12.4K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.4K
Chemical Synapses01:26

Chemical Synapses

8.1K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.1K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

3.1K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
3.1K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selecting outcome measures to validate prognostic biomarkers of paediatric mild traumatic brain injury: challenges and priorities.

Frontiers in neurology·2025
Same author

Can we trust published evidence on point-of-care tests for cholesterol? A rapid review.

BMJ open·2025
Same author

Artificial intelligence driven clustering of blood pressure profiles reveals frailty in orthostatic hypertension.

Experimental physiology·2024
Same author

Lipid Management in Primary Care for Socioeconomically Disadvantaged Populations in Northern England: A Qualitative Study.

Journal of primary care & community health·2024
Same author

Lipid-lowering optimisation for secondary prevention vascular and diabetic foot patients in a pharmacist-led clinic.

Journal of clinical lipidology·2024
Same author

Correction: Kujawski et al. Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Preliminary Study. <i>Medicina</i> 2020, <i>56</i>, 172.

Medicina (Kaunas, Lithuania)·2024

Related Experiment Video

Updated: Mar 23, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K

Understanding Muscle Dysfunction in Chronic Fatigue Syndrome.

Gina Rutherford1, Philip Manning1, Julia L Newton2

  • 1Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.

Journal of Aging Research
|March 22, 2016
PubMed
Summary

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) involves skeletal muscle biochemical abnormalities, specifically impaired energy production and acid clearance after exercise. These dysfunctions may explain the severe fatigue experienced by patients.

More Related Videos

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.9K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.3K

Related Experiment Videos

Last Updated: Mar 23, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.9K
Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.3K

Area of Science:

  • Biochemistry
  • Physiology
  • Pathophysiology

Background:

  • Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex disorder with unknown causes, often characterized by severe fatigue.
  • Previous psychological explanations for CFS/ME fatigue are challenged by evidence of underlying immune, oxidative, mitochondrial, and neuronal pathway dysfunctions.
  • Patients frequently report perceived lack of energy and difficulty maintaining muscle activity, suggesting a peripheral component to their fatigue.

Purpose of the Study:

  • To review existing literature for evidence of biochemical dysfunction in skeletal muscles of individuals with CFS/ME.
  • To investigate the role of skeletal muscle bioenergetics in the pathophysiology of CFS/ME.

Main Methods:

  • A narrative review of scientific literature was conducted.
  • Searches were performed on databases including PubMed, MEDLINE, and Google Scholar.
  • Keywords used were CFS/ME, immune, autoimmune, mitochondria, muscle, and acidosis.

Main Results:

  • Evidence indicates biochemical abnormalities in the skeletal muscle of CFS/ME patients.
  • A significant finding is the presence of bioenergetic dysfunction within skeletal muscles.
  • Studies suggest overutilization of the lactate dehydrogenase pathway and delayed acid clearance post-exercise in CFS/ME patients.

Conclusions:

  • Skeletal muscle bioenergetic dysfunction is a notable feature in CFS/ME.
  • Impaired energy metabolism and acid clearance in muscles following exercise may contribute to the debilitating fatigue characteristic of CFS/ME.