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The Host's Reply to Candida Biofilm
1University of Wisconsin-Madison, Departments of Medicine, Medical Microbiology and Immunology, 5203 Microbial Sciences Building, 1550 Linden Drive, Madison, WI 53706, USA. jenett@medicine.wisc.edu.
Pathogens (Basel, Switzerland)
|March 22, 2016
Summary
Candida species form biofilms on medical devices and mucosal surfaces, resisting host defenses. This review details recent findings on the host
Area of Science:
- Mycology
- Immunology
- Infectious Diseases
Background:
- Candida species are leading causes of hospital-acquired fungal infections.
- These fungi readily form biofilms, communities protected by a matrix, which resist host immune responses.
- Biofilms on medical devices and mucosal surfaces pose significant clinical challenges.
Purpose of the Study:
- To review recent advancements in understanding the host's response to Candida biofilms.
- To highlight findings from ex vivo and in vivo models of Candida biofilm infections.
Main Methods:
- Review of current literature on host response to Candida biofilms.
- Analysis of studies utilizing ex vivo and in vivo models.
- Focus on mucosal and device-associated biofilm infections.
Main Results:
- Candida biofilms are resistant to host immune cells like leukocytes.
- The host actively contributes to the biofilm matrix by depositing proteins.
- Recent models provide insights into the complex host-pathogen interactions within biofilms.
Conclusions:
- Understanding host responses is crucial for combating Candida biofilm infections.
- Further research using advanced models can elucidate mechanisms of resistance and host defense.
- Developing strategies to disrupt biofilm formation or enhance host immunity is essential.
