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Updated: Mar 23, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Metabolic syndrome and hypogonadism--two peas in a pod
Fahim Ebrahimi1, Mirjam Christ-Crain1
1Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland.
Abstract:
Testosterone deficiency is highly prevalent in up to 50% of men with the metabolic syndrome and type 2 diabetes mellitus. Low testosterone levels in men appear to be an independent cardiovascular risk factor and predictor of subsequent development of the metabolic syndrome. Reciprocally, the metabolic syndrome leads to a decrease in testosterone levels. This review provides an account of the pathophysiological mechanisms in the bidirectional relationship between hypogonadism and body composition, inflammation and insulin sensitivity as well as the effects of testosterone replacement on diverse metabolic parameters.
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