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Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet
Qiushui Chen1, Stefanie Utech2, Dong Chen2
1Department of Chemistry, Tsinghua University, Beijing 100084, PR China. jmlin@tsinghua.edu.cn and John A. Paulson School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02139, USA. weitz@seas.harvard.edu.
Lab on a Chip
|March 22, 2016
Abstract:
This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
