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Updated: Mar 23, 2026

Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges
Published on: February 25, 2016
Evaluation of autonomic nervous system function in children with overactive bladder syndrome
Aysegul Dogan Demir1, Azize Esra Gursoy2, Nilufer Goknar3
1Faculty of Medicine, Department of Pediatrics, Bezmialem Vakif University, Istanbul, Turkey.
Purpose:
We aimed to evaluate the autonomic nervous system activity in children with overactive bladder (OAB) syndrome.
Methods:
Included in the study were 40 children with overactive bladder and 28 healthy controls. Autonomic tests were performed on all participants, including heart rate interval variation (RRIV), heart rate response to valsalva maneuver, and sympathetic skin response (SSR).
Results:
Mean valsalva rates in the overactive bladder and control groups were 1.53 ± 0.29 and 1.30 ± 0.18, respectively, a statistically significant difference (P < 0.001). Also significantly different were deep breathing RRIV values of the study and control groups: 56.65 ± 14.66 and 47.92 ± 10.15, respectively (P = 0.008). No statistical differences were found in SSR when OAB patients were compared with controls (P > 0.05).
Conclusions:
This study demonstrated a parasympathetic hyperactivity in children with OAB, results suggesting a dysfunction in their autonomic nervous systems. Neurourol. Urodynam. 36:673-676, 2017. © 2016 Wiley Periodicals, Inc.
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