Related Experiment Video
Updated: Mar 23, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
[Associations of JAK1 gene polymorphisms with allergic rhinitis in Chinese Han populations]
Objective:
The aim of this study was to investigate the association of JAK1 polymorphisms with allergic rhinitis in China Han population.
Method:
A total of 450 patients with AR and 615 healthy subjects as control were genotyped for the presence of three single nucleotide polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PGR-RFLP) analysis of DNA extracted from blood samples.
Result:
All control subjects were in Hardy-Weinberg equilibrium, but high frequencies of JAK1 the homozygous rs310241 CC genotype were observed in AR patients compared to controls (P < 0.05). The results also revealed that there was no association between the rest of two investigated SNPs and AR.
Conclusion:
Our results suggested that JAK1 gene rs310241 CC genotype was associated with patients with AR.
More Related Videos
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
06:08Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
The JAK-STAT Signaling Pathway
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Cross-reactivity