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Related Concept Videos

Continuing Care01:25

Continuing Care

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Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Therapies02:49

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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Mar 23, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Palliative chemotherapy: oxymoron or misunderstanding?

E J Roeland1, T W LeBlanc2

  • 1Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA. eroeland@ucsd.edu.

BMC Palliative Care
|March 23, 2016
PubMed
Summary

Patient-reported outcomes can help predict responses to palliative chemotherapy in advanced cancer. This research aims to improve clinical decisions for chemotherapy

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Area of Science:

  • Oncology
  • Palliative Care
  • Clinical Decision-Making

Background:

  • Chemotherapy is often used for advanced cancer, but its palliative role is sometimes misunderstood.
  • Palliative chemotherapy aims to improve symptom control, quality of life, and survival in non-curative settings.
  • Oncologists currently lack precise tools to identify patients who will benefit from palliative chemotherapy.

Purpose of the Study:

  • To explore the use of patient-reported outcomes (PROs) as a predictive tool for chemotherapy response.
  • To advance the science of predicting benefits from palliative chemotherapy.

Main Methods:

  • Utilized patient-reported outcomes to analyze responses to palliative chemotherapy.
  • Focused on data from a study published in BMC Palliative Care by Creutzfeldt et al.

Main Results:

  • Patient-reported outcomes show promise in predicting responses to palliative chemotherapy.
  • This approach offers an innovative way to advance the science in this field.

Conclusions:

  • Further research may lead to bedside predictive models for palliative chemotherapy.
  • Collaboration between oncologists and palliative care clinicians is crucial.
  • Distinguish between beneficial palliative chemotherapy and non-beneficial 'end-of-life chemotherapy'.