Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.9K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.9K
Antibiotic Selection00:57

Antibiotic Selection

62.0K
Overview
62.0K
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

47
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
47
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

21
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
21
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.4K
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

19
Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody.

Nature communications·2026
Same author

Phthalimide derivatives as a new class of papain-like protease inhibitors in SARS-CoV-2.

Archiv der Pharmazie·2024
Same author

Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.

Chemical science·2024
Same author

Structure and supramolecular organization of the canine distemper virus attachment glycoprotein.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Structure of a hydrophobic leucinostatin derivative determined by host lattice display.

Acta crystallographica. Section D, Structural biology·2022
Same author

Discovery of a Dual SENP1 and SENP2 Inhibitor.

International journal of molecular sciences·2022
Same journal

The Role of Zn-Hf Site Proximity and Oxygen Vacancies for Methanol Formation Over ZnHfO<sub>x</sub> Catalysts Under CO<sub>2</sub> Hydrogenation Conditions.

Angewandte Chemie (International ed. in English)·2026
Same journal

Breaking the Linear Scaling Relationship: Bioinspired Electronic Coupling in S-Bridged Fe-Fe Dual Sites for Efficient Oxygen Reduction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Programming Bio-Bio Electronic Interfaces for Light-Driven Interspecies Electron Transfer.

Angewandte Chemie (International ed. in English)·2026
Same journal

Self-Cleaning Solar Evaporation Facilitating Water Electrolysis for Hydrogen Generation From Seawater.

Angewandte Chemie (International ed. in English)·2026
Same journal

Sulfur Vacancy-Enriched Cu<sub>4</sub>SnS<sub>4-x</sub> Nanosheets Enable Synergistic Cuproptosis, Photothermoelectric Catalytic and Immunotherapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Mechanically Interlocked Indigo Photoswitches.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Mar 23, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.3K

Targeting Antibiotic Resistance.

Mathieu F Chellat1, Luka Raguž1, Rainer Riedl2

  • 1Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820, Wädenswil, Switzerland.

Angewandte Chemie (International Ed. in English)
|March 23, 2016
PubMed
Summary
This summary is machine-generated.

Antibiotic resistance is a growing global threat, with rising infections unresponsive to drugs. New strategies are emerging to combat resistant bacteria and restore effective treatments.

Keywords:
antibiotic resistanceantibioticsdrug designmedicinal chemistrystructure-activity relationships

More Related Videos

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K
Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

14.8K

Related Experiment Videos

Last Updated: Mar 23, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

8.3K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

12.5K
Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

14.8K

Area of Science:

  • Microbiology
  • Public Health
  • Infectious Diseases

Background:

  • Antibiotic resistance is a significant global challenge, marked by increasing infections from bacteria resistant to multiple antibiotics.
  • Conventional treatments are failing, and even last-resort antibiotics are losing efficacy against resistant pathogens.
  • The development pipeline for new antibiotics has significantly slowed in recent decades.

Purpose of the Study:

  • To address the critical need for strategies against escalating antibiotic resistance.
  • To review and highlight promising new approaches to combat drug-resistant bacterial infections.
  • To inform the life sciences and public health communities about advancements in fighting antimicrobial resistance.

Main Methods:

  • Review of current research and development in antibiotic resistance strategies.
  • Analysis of emerging therapeutic approaches and their potential.
  • Synthesis of information on global efforts to combat drug resistance.

Main Results:

  • Several promising strategies have been identified to restore treatment options against resistant bacterial pathogens.
  • Increased research activity is noted following global health initiatives.
  • The development of novel approaches is crucial for managing infections caused by resistant microorganisms.

Conclusions:

  • Combating antibiotic resistance requires urgent and sustained global action.
  • New strategies are vital to overcome the limitations of current treatments.
  • Continued research and development are essential to ensure future cures for resistant infections.