Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.0K
Overview
86.0K
Tissue Transplantation01:24

Tissue Transplantation

1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unmanipulated haploidentical versus matched unrelated donor allogeneic stem cell transplantation in adult patients with acute myelogenous leukemia in first remission: a retrospective pair-matched comparative study of the Beijing approach with the EBMT database.

Haematologica·2016
Same author

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Journal of hematology & oncology·2016
Same author

Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia.

BMC cancer·2016
Same author

Haploidentical hematopoietic stem cell transplantation for paediatric high-risk T-cell acute lymphoblastic leukaemia.

Pediatric transplantation·2016
Same author

Homoharringtonine, aclarubicin and cytarabine (HAA) regimen as the first course of induction therapy is highly effective for acute myeloid leukemia with t (8;21).

Leukemia research·2016
Same author

Allogeneic Stem Cell Transplantation for Patients with T315I BCR-ABL Mutated Chronic Myeloid Leukemia.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2016

Related Experiment Video

Updated: Mar 23, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

15.0K

Haploidentical stem cell transplantation: anti-thymocyte globulin-based experience.

Ying-Jun Chang1, Xiao-Jun Huang2

  • 1Peking University People׳s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.

Seminars in Hematology
|March 23, 2016
PubMed
Summary

Haploidentical stem cell transplantation using anti-thymocyte globulin (ATG) offers immune tolerance, fast recovery, and reduced graft-versus-host disease (GVHD). This method shows survival rates comparable to matched sibling or unrelated donor transplants for hematological diseases.

Keywords:
Anti-thymocyte globulinHaploidentical stem cell transplantationHematological malignanciesMyeloablative conditioningReduced-intensity conditioning

More Related Videos

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

7.7K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.3K

Related Experiment Videos

Last Updated: Mar 23, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

15.0K
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
10:44

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

Published on: August 9, 2019

7.7K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.3K

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Haploidentical stem cell transplantation (haplo-SCT) is a vital treatment for hematological malignancies.
  • Traditional haplo-SCT protocols faced challenges like graft rejection and graft-versus-host disease (GVHD).
  • Anti-thymocyte globulin (ATG) has emerged as a key component in conditioning regimens.

Purpose of the Study:

  • To evaluate the efficacy and safety of haplo-SCT with an ATG preparative regimen.
  • To assess outcomes including immune tolerance, hematopoietic recovery, GVHD, and non-relapse mortality (NRM).
  • To compare unmanipulated haploidentical blood and marrow transplantation (HBMT) outcomes with other donor sources.

Main Methods:

  • Utilizing an ATG-based preparative regimen in haplo-SCT.
  • Employing unmanipulated grafts in HBMT.
  • Analyzing patient data for survival rates, GVHD incidence, and NRM.

Main Results:

  • ATG-based haplo-SCT induces immune tolerance, promotes rapid hematopoietic recovery, and effectively prevents GVHD.
  • This protocol is associated with significantly lower NRM.
  • Survival rates in HBMT with ATG are comparable to HLA-matched sibling or unrelated donor transplantation.
  • Unmanipulated HBMT is a viable post-remission strategy for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) with unfavorable cytogenetics.

Conclusions:

  • ATG-based haplo-SCT is a safe and effective strategy for hematological diseases.
  • Unmanipulated HBMT with ATG offers outcomes comparable to other donor types.
  • Future research should refine donor selection, optimize grafts, and address graft failure and relapse.