[The role of flavonoids in the modulation of inflammation]

Chronic inflammation in the body leads to the formation and development many diseases, e.g. atherosclerosis, diabetes, neurodegenerative diseases or cancer and others. Therefore, the search for new and safe compounds of plant origin having antiinflammatory activity. They include, among others, naturally occurring in the diet of human - flavonoids. Anti-inflammatory effects of these compounds is due to their antioxidant properties, ability to inhibit enzymes involved in the metabolism of eicosanoids and proinflammatory molecules and modulate the expression of certain proinflammatory genes. Intensive studies in vitro and in vivo antiinflammatory activity of flavonoids are important not only because of the knowledge of the mechanisms of action of these compounds, but also to develop a new class of safe anti-inflammatory drugs of plant origin. This should bring prophylactic and therapeutic benefits. A diet rich in flavonoid compounds and/or supplementation with these compounds not only improve the efficiency of prevention of nutrition, but also complement the medical therapy of many diseases.