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Updated: Mar 23, 2026

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
The pharmacological management of psychiatric comorbidities in patients with epilepsy
1Atkinson Morley Regional Neuroscience Centre, St. Georges University Hospitals NHS Foundation Trust, London, United Kingdom; South West London & St. Georges Mental Health Trust, London, United Kingdom; Institute of Medical and Biomedical Sciences, St. Georges University of London, United Kingdom.
Abstract:
Psychiatric disorders represent a frequent comorbidity in patients with epilepsy affecting quality of life, morbidity and mortality. Evidence-based data on the management of these conditions are limited but a number of recommendations are now available to guide clinical practice. The present paper reviews the pharmacological treatment of psychiatric problems in epilepsy with special attention to data coming from randomised controlled trials (RCTs), pharmacological interactions with AEDs and the issue of seizure worsening during treatment with psychotropic drugs. Epidemiologically or clinically relevant psychiatric conditions are discussed namely mood and anxiety disorders, psychoses and attention deficit hyperactivity disorder.
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