Related Experiment Video

Updated: Mar 23, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.5K

Drug Reaction with Eosinophilia and Systemic Symptoms in Children: A Prospective Study

Sarita Sasidharanpillai1, Sasidharanpillai Sabitha2, Najeeba Riyaz1

  • 1Department of Dermatology, Government Medical College, Kozhikode, Kozhikode, Kerala, India.

Pediatric Dermatology
|March 23, 2016
PubMed

Insights

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in children is a severe reaction often caused by lamotrigine or penicillins. Careful drug titration may prevent DRESS, especially with lamotrigine.

Area of Science:

  • Pediatric Dermatology
  • Clinical Pharmacology
  • Adverse Drug Reactions

Background:

  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe adverse drug reaction impacting all age groups.
  • Understanding DRESS in pediatric populations is crucial for timely diagnosis and management.

Purpose of the Study:

  • To prospectively investigate the clinicoepidemiologic features of DRESS in children.
  • To identify common causative agents and risk factors for DRESS in pediatric patients.

Main Methods:

  • Prospective study of children (≤12 years) with probable or definite DRESS over 3 years at a tertiary care hospital.
  • Diagnosis and severity assessment based on the RegiSCAR scoring system.
  • Analysis of clinical data, including offending drugs and latent periods.

Main Results:

  • Eleven pediatric patients with DRESS were identified.
  • Lamotrigine (4 patients) and penicillins (3 patients) were the most frequent culprits.
  • Suboptimal lamotrigine dosing and short latent periods for antibiotics were observed.

Conclusions:

  • Lamotrigine and penicillins are significant causes of DRESS in children.
  • Adherence to standard drug titration guidelines may mitigate lamotrigine-induced DRESS risk.
  • Antibiotic-associated DRESS may present with a shorter onset latency.

More Related Videos

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.6K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.1K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
33.4K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
149
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
129
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.3K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
2.2K