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A Practical and Novel Method to Extract Genomic DNA from Blood Collection Kits for Plasma Protein Preservation

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Published on: May 18, 2013

Comprehensive US government program for dried plasma development.

Anthony E Pusateri¹, Michael B Given², Victor W Macdonald³

¹US Army Medical Research and Materiel Command, Fort Detrick, Maryland.

|March 23, 2016

Summary

This summary is machine-generated.

Early plasma transfusion improves survival after severe injury. Development of FDA-approved dried plasma is crucial for military and emergency use in austere settings.

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Area of Science:

Trauma and Emergency Medicine
Blood Products and Transfusion Medicine
Biomedical Product Development

Background:

Early plasma transfusion is linked to better survival rates in severe trauma patients.
Logistical challenges hinder timely plasma delivery in austere environments like battlefields or emergencies.
The United States currently lacks an FDA-approved dried plasma product for widespread use.

Purpose of the Study:

To address the need for an FDA-approved dried plasma product for military and civilian emergency use.
To support the development of logistically feasible dried plasma for remote and austere settings.
To advance the understanding and application of plasma use in critical care scenarios.

Main Methods:

The Department of Defense (DoD) and Biomedical Advanced Research and Development Authority are funding the development of three distinct dried plasma products.
Prospective, randomized clinical studies are being conducted by the DoD to evaluate prehospital plasma administration.
Concurrent development of dried plasma products and clinical research on their use.

Main Results:

Multiple technological approaches and business models are being explored for dried plasma development.
Clinical studies are gathering essential data on the efficacy and safety of prehospital plasma transfusion.
Progress is being made towards a coordinated program for dried plasma availability and application knowledge.

Conclusions:

There is a critical need for an FDA-approved dried plasma product in the US for emergency and military applications.
Ongoing research and development aim to provide a stable, accessible dried plasma product for use in austere environments.
The coordinated efforts will enhance both the availability and the evidence-based utilization of plasma therapy in critical situations.