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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Umbilical cord and preeclampsia.
M Olaya-C1, J Salcedo-Betancourt2, S H Galvis2
1Department of Pathology, Pontificia Universidad Javeriana School of Medicine, Bogota, Colombia- San Ignacio University Hospital, Bogota, Colombia.
Journal of Neonatal-Perinatal Medicine
|March 23, 2016
Summary
Umbilical cord abnormalities like length and insertion are linked to maternal gestational hypertension. These findings highlight potential fetal and neonatal risks in pregnancies with hypertensive disorders.
Area of Science:
- Obstetrics and Gynecology
- Perinatology
- Fetal Medicine
Background:
- Preeclampsia involves diverse umbilical cord abnormalities (morphological, biochemical, functional).
- Placental, decidual, and fetal circulatory alterations may link to preeclampsia and cord issues.
Purpose of the Study:
- To investigate the association between specific umbilical cord abnormalities and hypertensive gestational disorders.
- To clarify the relationship between various cord anomalies and subtypes of hypertension in pregnancy.
Main Methods:
- Prospective autopsy study of placentas.
- Systematic examination of umbilical cord features (length, diameter, insertion, etc.).
- Correlation of cord findings with clinical data on maternal hypertensive disorders.
Main Results:
- Umbilical cord abnormalities, including variations in length, diameter, insertion, entanglements, knots, and coils, were significantly associated with maternal gestational hypertension.
- Specific types of cord anomalies demonstrated varying degrees of association with hypertensive conditions.
Conclusions:
- Umbilical cord abnormalities are frequently observed in pregnancies complicated by gestational hypertension.
- These abnormalities carry implications for fetal and neonatal outcomes in women with hypertensive disorders of pregnancy.
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