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Allergic Reactions

Allergic Reactions

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...

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Updated: Mar 23, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Pollen Allergens for Molecular Diagnosis.

Isabel Pablos¹, Sabrina Wildner², Claudia Asam¹

¹Department of Molecular Biology, University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.

Current Allergy and Asthma Reports

|March 23, 2016

Summary

Pollen allergens cause type I allergies, with climate change worsening symptoms. Molecule-based diagnostics improve accuracy for precise allergy diagnosis and immunotherapy.

Keywords:

Grass pollen allergens Molecule-based diagnosis Pollen allergens Tree pollen allergens Weed pollen allergens

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Last Updated: Mar 23, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

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Published on: November 19, 2016

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Environmental Science
Immunology
Allergy Research

Background:

Pollen allergens are a major cause of type I allergies, affecting up to 30% of people in industrialized nations.
Climate change and pollution are increasing respiratory allergies and asthma by altering pollen seasons.
Similarities in habitats and flowering times of allergenic plants complicate traditional allergy diagnosis.

Purpose of the Study:

To review key pollen allergens and their practical applications in allergy diagnosis.
To highlight the role of molecule-based diagnostics in distinguishing true sensitization from cross-reactivity.
To emphasize the importance of accurate diagnosis for effective allergen immunotherapy and precision medicine.

Main Methods:

Review of current scientific literature on pollen allergens and diagnostic approaches.
Analysis of molecule-based diagnostic strategies, including IgE testing.
Discussion of the clinical utility of specific allergen identification.

Main Results:

Molecule-based diagnostics enhance sensitivity and specificity in allergy testing.
These methods differentiate genuine sensitization from cross-reactivity to panallergens or carbohydrate determinants.
Identification of primary sensitizing sources is crucial for polysensitized individuals.

Conclusions:

Accurate allergy diagnosis, particularly with molecule-based approaches, is essential for effective treatment decisions.
Reliable biomarkers are critical for guiding allergen immunotherapy within a precision medicine framework.
Understanding specific pollen sensitivities improves patient management and therapeutic outcomes.