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[Clinical analysis of 18 cases of E. coli septicemia in children]
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|November 15, 1989
Insights
Escherichia coli (E. coli) septicemia predominantly affects infants under six months, often originating in hospitals. Thrombocytopenia is a key lab finding, with most E. coli strains remaining sensitive to gentamicin.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatology
Context:
- Escherichia coli (E. coli) septicemia is a serious bloodstream infection.
- Neonatal and infant populations are particularly vulnerable.
- Hospital-acquired infections present a significant challenge.
Purpose:
- To analyze clinical features, laboratory findings, and outcomes of E. coli septicemia in children.
- To identify risk factors and common manifestations in the pediatric population.
- To assess antimicrobial susceptibility patterns.
Summary:
- A review of 18 pediatric E. coli septicemia cases revealed 90% occurred in infants under six months, with half hospital-acquired.
- Loose stools were the most common non-specific symptom, while thrombocytopenia was the most characteristic laboratory abnormality.
- All but one E. coli strain were susceptible to gentamicin, and the overall mortality rate was 16.7%.
Impact:
- Highlights the vulnerability of neonates and young infants to E. coli septicemia.
- Emphasizes the importance of monitoring for thrombocytopenia in suspected cases.
- Informs empirical antibiotic treatment strategies, noting gentamicin sensitivity.
Abstract:
A clinical analysis of 18 cases of E. coli septicaemia in children showed that 90% of cases were in infants aged up to 6 months, mainly in newborns. Half the cases developed in hospital. All strains with one exception were sensitive to gentamicin. In the whole complex of non-characteristic clinical manifestations loose stools were most frequent. In the laboratory investigations thrombocytopenia was the most characteristic abnormality. The mortality was 16.7%.