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CETP Inhibition in CVD Prevention: an Actual Appraisal

Belinda Di Bartolo1, Kohei Takata1, MyNgan Duong1

  • 1South Australian Health and Medical Research Institute, University of Adelaide, PO Box 11060, Adelaide, SA, 5001, Australia.

Current Cardiology Reports
|March 23, 2016
PubMed

Insights

Pharmacological inhibitors of cholesteryl ester transfer protein (CETP) show promise for preventing cardiovascular disease by favorably altering cholesterol levels. Research continues on developing safer CETP inhibitors after early setbacks.

Area of Science:

  • Cardiovascular pharmacology
  • Lipid metabolism research
  • Drug development for cardiovascular disease

Background:

  • Cholesteryl ester transfer protein (CETP) plays a role in cholesterol transport.
  • Genetic and animal studies indicate reduced CETP activity is beneficial for cardiovascular health.
  • Previous CETP inhibitor (torcetrapib) development was halted due to adverse effects.

Purpose of the Study:

  • To review the potential of pharmacological CETP inhibitors for cardiovascular disease prevention.
  • To discuss the development of novel CETP inhibitors.
  • To highlight promising CETP inhibitor candidates in clinical development.

Main Methods:

  • Review of existing scientific literature and clinical trial data.
  • Analysis of genetic and animal studies on CETP activity.
  • Evaluation of the pharmacological profiles of CETP inhibitors.

Main Results:

  • CETP inhibition favorably impacts low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and cellular cholesterol efflux.
  • Despite torcetrapib's issues, alternative CETP inhibitors are being developed.
  • Several promising CETP inhibitors are progressing through clinical development.

Conclusions:

  • CETP inhibitors represent a potential novel strategy for cardiovascular disease prevention.
  • Continued research is focused on developing CETP inhibitors with improved safety profiles.
  • The development pipeline includes promising candidates for future cardiovascular therapies.
Keywords:
AtherosclerosisCETP inhibitorsCardiovascular diseaseClinical trialsLipidsPrevention

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