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Hypertension, Blood Pressure Variability, and Target Organ Lesion

Maria-Cláudia Irigoyen1, Kátia De Angelis2, Fernando Dos Santos3

  • 1Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-900, São Paulo, SP, Brazil. hipirigoyen@incor.usp.br.

Current Hypertension Reports
|March 23, 2016
PubMed

Insights

Hypertension increases cardiovascular risks. This review explores how blood pressure variability (BPV) may worsen target organ damage in hypertensive patients, impacting overall cardiovascular health.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Autonomic Nervous System Function

Background:

  • Hypertension poses significant risks for cardiovascular (CV) events.
  • Complication severity correlates with blood pressure (BP) elevation and associated CV risk factors.
  • Managing BP and target organ damage is crucial for risk reduction.

Purpose of the Study:

  • To review evidence linking BP variability (BPV) to target organ damage in hypertension.
  • To explore the role of BPV as a marker of autonomic nervous system dysfunction in hypertensive individuals.

Main Methods:

  • Literature review of clinical and experimental studies.
  • Analysis of data relating BPV measurements to indicators of target organ damage.
  • Examination of the physiological basis of BPV in hypertension.

Main Results:

  • BPV is associated with increased cardiovascular risk in hypertensive patients.
  • Evidence suggests BPV contributes to target organ damage.
  • Autonomic nervous system dysregulation may underlie the link between BPV and organ damage.

Conclusions:

  • BPV is a significant factor in hypertension-related complications.
  • Further research into BPV management could improve patient outcomes.
  • Understanding BPV's role is key to mitigating cardiovascular risk in hypertension.

Keywords:
Autonomic dysfunctionBlood pressure variabilityHypertensionTarget-organ damage

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