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Updated: Mar 23, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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An Engineered Endomorphin-2 Gene for Morphine Withdrawal Syndrome

Fei-Xiang Wu1,2, Yan He3, Hui-Ting Di1

  • 1Department of Anesthesiology & Intensive Care, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.

Plos One
|March 23, 2016
PubMed
Summary

Increasing endomorphin-2 (EM2) levels via gene therapy in the central nervous system can effectively manage morphine withdrawal symptoms. This novel approach offers a promising treatment for opioid addiction by sustaining EM2 release and reducing withdrawal syndrome.

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