[Research progress of Epstein-Barr virus-associated gastric carcinoma]

Epstein-Barr virus-associated gastric carcinoma(EBVaGC) comprises nearly 10% of gastric carcinoma in the world. EBVaGC is supposed to have distinct clinicopathological features, including male predominance, the 'lace pattern' in the early stage, lower rate of lymph node involvement and infiltration of a large number of various inflammatory cells. EBER-ISH detection is the golden standard in the diagnosis of EBVaGC. Although there is no special therapy due to the limited understanding, EBVaGC has a better prognosis. In this paper, the relationship of EBV with gastric carcinoma, the epidemiological and clinical features of EBVaGC will be briefly introduced. In addition, the clinical diagnosis, treatment, and the prognosis of the status quo will be discussed.