Related Experiment Video
Updated: Mar 23, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical
E E Camarena Pulido1, L García Benavides2, J G Panduro Barón1
1a Unidad de Investigación División de Ginecología y Obstetricia, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" , Guadalajara , Jalisco , Mexico.
Objective:
This study aimed to estimate the effectiveness of L-arginine for preventing preeclampsia in high-risk pregnancy.
Methods:
We performed a randomized, double-blind, placebo-controlled, clinical trial in patients with high-risk factors for preeclampsia. Fifty subjects received L-arginine, beginning from the 20th week of gestation. An additional 50 patients received homologated placebo.
Results:
The placebo group had a higher number of cases of preeclampsia (11/47) compared with the L-arginine group (3/49, P = 0.01). Birth weight was higher in the L-arginine group and there was a smaller number of preterm births (P = 0.03).
Conclusion:
L-arginine is effective for preventing preeclampsia.
Related Concept Videos
Hormonal Regulation
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Atherosclerosis III: Management
Adrenergic Antagonists: ɑ and β-Receptor Blockers

