Morphometric differentiation of squamous cell carcinoma and adenocarcinoma of the cervix

The aim of the study was to define the morphometric characteristics of squamous cell carcinoma (SCC) and adenocarcinoma (AC) cells and identify opportunities to differentiate these tumors based on determination of the morphometric characteristics in order to use the results of research in the diagnosis of cervical cancer. Pap smears with two histopathologically confirmed cervix cancers were used for testing. For the morphometric assessment of cancer cells the dotSlide program was used. The mean nucleus area for AC cells was 126.62 × 10(-6) m(2), while this value for SCC was 145.07 × 10(-6) m(2) (p = 0.000132). The mean circumference of AC cells was 42.43 × 10(-6) m, while for SCC cells it was 46.67 × 10(-6) m (p = 0.00). AC cell diameter was 13.83 µm, whereas for SCC cells it was 15.36 × 10(-6) m. On average the AC cell surface area was 195.72 × 10(-6) m(2), while for SCC cells it was 249.94 × 10(-6) m(2) (p = 0.00565). The mean AC cell circumference was 54.90 μm, whereas for SCC cells it was 65.23 × 10(-6) m (p = 0.00607). The research shows that, despite the presence of statistically significant differences for each morphometric parameter, determination of cancer type cannot be used in the diagnosis.