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Current Status: Site-Specific Antibody Drug Conjugates

Dominik Schumacher1, Christian P R Hackenberger1, Heinrich Leonhardt2

  • 1Chemical Biology and Department of Chemistry, Leibniz-Institut für Molekulare Pharmakologie and Humboldt Universität zu Berlin, Berlin, Germany.

Journal of Clinical Immunology
|March 23, 2016
PubMed

Keywords:
Antibody drug conjugates (ADCs)Sortase ATHIOMABTub-tagdrug-antibody ratio (DAR)formylglycine generating enzyme (FGE)microbial transglutaminase (MTG)monomethyl auristatin E/F (MMAE/MMAF)site-specific conjugationtherapeutic windowtubulin tyrosine ligase (TTL)unnatural amino acids (UAA)

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