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Citrate-Based Biomaterials and Their Applications in Regenerative Engineering.
Richard T Tran1, Jian Yang1, Guillermo A Ameer2
1Department of Biomedical Engineering, Materials Research Institute, and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802.
Annual Review of Materials Research
|March 23, 2016
Summary
Citrate-based biomaterials offer unique antioxidant and antimicrobial properties, advancing regenerative engineering. This review explores their design and functionality for creating complex tissues in clinical applications.
Area of Science:
- Biomaterials Science and Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Regenerative engineering aims to clinically translate complex tissue recreation.
- Advances in biomaterials are essential for this translation.
- Citrate-based biomaterials possess versatile material and biological properties.
Purpose of the Study:
- To review fundamental design considerations for citrate-based biomaterials.
- To discuss strategies for incorporating unique functionalities into these materials.
- To highlight examples of citrate-based biomaterials enabling regenerative engineering.
Main Methods:
- Literature review of citrate-based biomaterials.
- Analysis of material and biological characteristics.
- Case study examples in regenerative engineering.
Main Results:
- Citrate-based biomaterials exhibit antioxidant, antimicrobial, adhesive, and fluorescent properties.
- Design strategies allow for tailored functionality.
- These materials show promise for various regenerative engineering applications.
Conclusions:
- Citrate-based biomaterials are a key enabling technology for regenerative engineering.
- Their unique properties facilitate tissue regeneration and clinical translation.
- Further research into design and application is warranted.
