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Efficient antisense oligonucleotide delivery via non-covalent complexes of folic acid and modified polyethylenimine

Shuang Yang1, Xuewei Yang1, Jing Xie1

  • 1Institute of Life Sciences, Jilin University, Changchun 130012, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 24, 2016
PubMed
Abstract

No abstract available in PubMed .

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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