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The correlation between the Glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors
Xinling Wu1, Youmin Zhao1, Jianwen Chai1
1Department of cardiovascular, People's Hospital of Zhengzhou University, Zhengzhou, China.
Insights
Elevated glycated hemoglobin (HbA1c) levels in non-diabetics (6.0%-6.5%) correlate with increased cardiovascular risk factors. HbA1c can predict these risks, especially in individuals with impaired glucose tolerance or fasting blood glucose.
Area of Science:
- Cardiovascular Health
- Endocrinology
- Preventive Medicine
Background:
- Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
- Early identification of cardiovascular risk factors is crucial for effective prevention strategies.
- The role of glycated hemoglobin (HbA1c) in non-diabetic individuals as a predictor of cardiovascular risk warrants further investigation.
Purpose of the Study:
- To examine the relationship between HbA1c levels in non-diabetic adults and various cardiovascular risk factors.
- To determine the predictive significance of HbA1c for cardiovascular risk in a general population.
- To identify specific HbA1c thresholds associated with increased cardiovascular risk.
Main Methods:
- Cross-sectional study involving 2007 community-dwelling non-diabetic adults.
- Data collection included demographic information, anthropometrics, blood pressure, lipid profiles, fasting blood glucose (FBG), and HbA1c levels.
- Cardiovascular risk factors defined as hypertension, dyslipidemia, overweight/obesity, age, HbA1c ≥ 6.0%, and FBG ≥ 6.1 mmol/L.
Main Results:
- A positive correlation was observed between increasing HbA1c levels and the frequency of cardiovascular risk factors, particularly in individuals with three or more risk factors.
- HbA1c levels significantly increased across groups defined by an increasing number of cardiovascular risk factors (P<0.001).
- Regression analysis indicated a stronger association between HbA1c and impaired glucose tolerance (IGT) and FBG compared to age.
Conclusions:
- Non-diabetic individuals with HbA1c levels between 6.0% and 6.5% are at a heightened risk of developing cardiovascular risk factors.
- HbA1c serves as a valuable predictive index for cardiovascular risk in non-diabetics, independent of other established risk factors.
- HbA1c levels demonstrate a strong relevance to IGT and impaired FBG, underscoring its utility in cardiovascular risk assessment.
Abstract:
This study aimed to discuss the relativity between the glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors and definite the significance of predicting the cardiovascular risk factors through cross-sectional research method. There were 2007 cases volunteers (including 650 cases of male, 1357 cases of female) from city community with complete information involved in the research of diabetes. The value of HbA1c 6.5% was set as the diagnose boundary of the diabetes. Differences were considered to be statistically significant at P<0.05. Hypertension, dyslipidemi, being overweight or obesity, age (male was over 45 years old and female was over 55 years old.), HbA1c 6.0% and fasting blood glucose (FBG) 6.1mmol/L were regarded as cardiovascular risk factors. Then we analyzed the number of risk factors for individuals in different HbA1c groups. Meanwhile, patients were grouped into zero, one, two, three, four or more groups with reference to the number of risk factors they had in order to compare the values of risk factors in different groups through Logistic regression. The results showed that (1) For those people who had no less than three risk factors, the frequency of risk factors was on the rise with the increase of HbA1c levels. (2) The value of HbA1c in different groups of risk factors rose with the increasing number of risk factors. There was a significant difference (P<0.001) between groups. (3) The Regression analysis showed that there was a stronger correlation between HbA1c levels and impaired glucose tolerance (IGT), fasting blood glucose (FBG) rather than age. So Non-diabetics whose HbA1c levels ranged from 6.0% to 6.5% were at high risk of cardiovascular risk factors. HbA1c levels, which can be a prediction index for cardiovascular risk factors dependent from other cardiovascular risk factors for non-diabetics, and it were highly relevant with impaired glucose tolerance (IGT) and impaired fasting blood glucose (FBG).
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