Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological aspects on IDDM in children.

J Ludvigsson

    Indian Journal of Pediatrics
    |November 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Childhood diabetes involves immune responses potentially causing beta cell destruction. Evidence supports an autoimmune cause, prompting research into specific therapies beyond broad immunosuppression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The importance of factors early in life for development of eating disorders in young people, with some focus on type 1 diabetes.

    Eating and weight disorders : EWD·2024
    Same author

    Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in type 1 diabetes.

    Immunotherapy advances·2022
    Same author

    Glycemic control and complications of type 1 diabetes among children in Tanzania.

    Journal of clinical & translational endocrinology·2020
    Same author

    LDL cholesterol level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes mellitus: A nationwide cohort study.

    Journal of internal medicine·2020
    Same author

    European dermatology forum - updated guidelines on the use of extracorporeal photopheresis 2020 - part 1.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    European dermatology forum: Updated guidelines on the use of extracorporeal photopheresis 2020 - Part 2.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020

    Area of Science:

    • Immunology
    • Endocrinology
    • Pediatrics

    Background:

    • Childhood diabetes mellitus is linked to immunological phenomena.
    • While not definitive proof, evidence increasingly supports an autoimmune basis for beta cell destruction.
    • Mechanisms may be secondary, but strong indicators exist.

    Purpose of the Study:

    • To review evidence supporting the autoimmune hypothesis in childhood diabetes.
    • To explore the role of cell-mediated and humoral immunity.
    • To discuss potential future therapeutic strategies.

    Main Methods:

    • Review of existing literature and evidence.
    • Analysis of immunological factors in diabetes pathogenesis.
    • Discussion of therapeutic implications.

    Related Experiment Videos

    Main Results:

    • Evidence supports autoimmune destruction of beta cells, including twin studies and immunosuppression effects.
    • Cell-mediated immunity (T-cells in insulitis) appears significant.
    • Humoral factors, interleukins, lymphokines, and free radicals are under investigation.

    Conclusions:

    • Autoimmune mechanisms are strongly implicated in childhood diabetes.
    • Current broad immunosuppression has severe side effects, especially in children.
    • Future therapies may involve specific interventions like vaccination or monoclonal antibodies, with supportive measures being a current practical approach.