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Updated: Mar 23, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive
George M Burslem1, Hannah F Kyle2, Panchami Prabhakaran1
1School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK. a.j.wilson@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS29JT, UK.
Abstract:
α-Helix proteomimetics represent an emerging class of ligands that can be used to inhibit an array of helix mediated protein-protein interactions. Within this class of inhibitor, aromatic oligobenzamide foldamers have been widely and successfully used. This manuscript describes alternative syntheses of these compounds that can be used to access mimetics that are challenging to synthesize using previously described methodologies, permitting access to compounds functionalized with multiple sensitive side chains and accelerated library assembly through late stage derivatisation.
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