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Glycemic Status in Organophosphorus Poisoning

S Panda1, R Nanda2, M Mangaraj3

  • 1Department of Biochemistry and Medicine, SCB Medical College, Cuttack, Odisha, India.

Journal of Nepal Health Research Council
|March 24, 2016
PubMed
Abstract

Insights

Organophosphorus poisoning causes hyperglycemia, linked to oxidative stress and atropine dose. Monitoring blood glucose may help assess poisoning severity.

Area of Science:

  • Toxicology
  • Endocrinology
  • Clinical Chemistry

Background:

  • Organophosphorus (OP) poisoning presents with cholinergic symptoms and metabolic disturbances, notably hyperglycemia.
  • OP compounds inhibit acetylcholinesterase and induce oxidative stress, contributing to hyperglycemia.
  • Understanding glycemic changes in OP poisoning is crucial for patient management.

Purpose of the Study:

  • To evaluate the glycemic status in patients with organophosphorus poisoning.
  • To investigate the association between hyperglycemia and factors like oxidative stress and atropine dosage in OP poisoning.
  • To explore the potential of glycemic status as a severity marker for OP poisoning.

Main Methods:

  • A prospective study involving 102 adult patients with a history of OP poisoning.
  • Patients were classified into mild, moderate, and severe grades using the Peradeniya Organophosphorus Poisoning Scale.
  • Biochemical parameters, including serum malondialdehyde (MDA) and cholinesterase levels, were measured.

Main Results:

  • Hyperglycemia and glycosuria were prevalent, with 57% of hyperglycemia cases in the severe group.
  • Elevated random plasma glucose (RPG), serum MDA, and atropine dose correlated with increased poisoning severity.
  • A significant decrease in plasma glucose from admission to discharge was observed across all severity groups.

Conclusions:

  • Transient hyperglycemia in OP poisoning shows a significant positive association with elevated serum MDA and atropine dosage.
  • Glycemic status at admission may serve as an indicator for assessing the severity of organophosphorus poisoning.
Keywords:
Atropine; hyperglycemia; organophosphorus; oxidative stress; random plasma glucose.

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