Related Experiment Video
Updated: Mar 23, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Comparative study evaluating efficacy of sufentanil versus midazolam in preventing myoclonic movements following
Mohammad Alipour1, Masoumeh Tabari1, Azadeh Mokhtari Azad1
1Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Aims:
Myoclonus is a major side-effect following etomidate injection requiring use of medical intervention.
Material And Methods:
In this double-blinded clinical trial, 50 consecutive patients, randomly received sufentanil 0.2 μg/kg or midazolam 0.015 mg/kg, 90 s before induction of anesthesia with etomidate (0.3 mg/kg). Then, the patients were monitored for any myoclonic movements during anesthesia.
Results:
The incidence of myoclonus was 28% in the sufentanil group and 84% in the midazolam group. The frequency and intensity of myoclonus were significantly higher in the midazolam group, compared to the sufentanil group (P < 0.001). Myoclonus duration in the sufentanil and midazolam groups were 5.8 ± 13.2 and 69 ± 47.8 s, respectively (P < 0.0010).
Conclusion:
The frequency, intensity and duration of myoclonus in the midazolam group, were significantly more prevalent than the sufentanil group.
More Related Videos
03:02Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
Published on: July 25, 2025
14:52Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
Published on: January 13, 2018
Related Concept Videos
Parenteral Anesthetics: Overview
Inhalational Anesthetics: Overview
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Stages of General Anesthesia
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Peripherally and Centrally Acting Muscle Relaxants: A Comparison
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...