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Risk Factors for Hypogonadism in Male Patients with Type 2 Diabetes

Rendong Zheng1, Lin Cao1, Wen Cao1

  • 1Department of Endocrinology and Metabolism, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu 210028, China; Department of Endocrinology and Metabolism, Jiangsu Province Academy of Traditional Chinese Medicine, 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu 210028, China.

Journal of Diabetes Research
|March 24, 2016
PubMed
Abstract

Insights

Male hypogonadism is linked to type 2 diabetes. Higher BMI, insulin resistance, and lower LH are key risk factors for hypogonadism in diabetic men.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Diabetes Research

Background:

  • Male hypogonadism, defined by low serum testosterone, is associated with diabetes development.
  • Type 2 diabetes is a prevalent condition with potential links to hormonal imbalances.

Purpose of the Study:

  • To identify risk factors for hypogonadism in male patients diagnosed with type 2 diabetes.
  • To investigate the relationship between metabolic parameters and sex hormone levels in this population.

Main Methods:

  • 213 male patients with type 2 diabetes were categorized into low total testosterone (TT) and normal TT groups.
  • Measurements included blood glucose, lipids, insulin, sex hormones, and metabolic indices.
  • Correlations between metabolic index and sex hormone levels were analyzed.

Main Results:

  • The low TT group exhibited significantly higher BMI, fasting insulin (FINS), and HOMA insulin resistance index (HOMA-IR), with lower luteinizing hormone (LH).
  • Total testosterone (TT) showed negative correlations with BMI, waist circumference (WC), FINS, and HOMA-IR.
  • TT demonstrated positive correlations with LH and follicle-stimulating hormone (FSH).

Conclusions:

  • Obesity (BMI), metabolic syndrome (MS), insulin resistance (HOMA-IR), and LH are significant risk factors for hypogonadism in men with type 2 diabetes.
  • These findings highlight the interconnectedness of metabolic health and hormonal balance in diabetic males.

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