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Updated: Mar 23, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

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Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment

Jing Li1,2, Zuozhang Yang1, Yi Li3

  • 1Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, China.

Oncotarget
|March 24, 2016
PubMed

Insights

Chemoresistance in osteosarcoma (bone cancer) is a major challenge. This study reviews novel agents targeting cell death pathways like apoptosis, autophagy, and necroptosis to overcome this resistance in pediatric patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Osteosarcoma is the most common primary bone tumor in children and adolescents.
  • Current combined therapies (surgery, chemotherapy) improve survival but face chemoresistance.
  • Understanding cell death mechanisms is crucial for effective osteosarcoma treatment.

Purpose of the Study:

  • To review novel compounds, miRNAs, and proteins targeting cell death pathways in osteosarcoma.
  • To summarize how these agents regulate apoptosis, autophagy, and necroptosis.
  • To discuss the role of these agents in overcoming chemotherapy resistance.

Main Methods:

  • Literature review of studies on osteosarcoma cell death pathways.
  • Analysis of novel agents (compounds, miRNAs, proteins) affecting apoptosis, autophagy, and necroptosis.
  • Synthesis of current knowledge on chemoresistance mechanisms and potential therapeutic targets.

Main Results:

  • Various novel agents modulate apoptotic, autophagic, and necroptotic pathways in osteosarcoma cells.
  • Specific miRNAs and compounds show promise in sensitizing osteosarcoma to chemotherapy.
  • Proteins involved in cell death signaling are potential targets for overcoming drug resistance.

Conclusions:

  • Targeting apoptosis, autophagy, and necroptosis offers promising strategies to combat osteosarcoma chemoresistance.
  • Further research into novel agents and their mechanisms is essential for developing improved therapies.
  • Personalized treatment approaches based on molecular targets may enhance patient outcomes.
Keywords:
apoptosisautophagychemotherapy resistancenecroptosisosteosarcoma

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