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HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy

B Jin1, B W Wu1, Z C Wen1

  • 1Department of Cardiology, Huashan Hospital, Fudan University, China.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|March 24, 2016
PubMed

Insights

Individuals with the HLA-DR3 antigen may be protected against idiopathic dilated cardiomyopathy (IDC). This meta-analysis found a decreased frequency of the HLA-DR3 allele in IDC patients, suggesting a protective genetic role.

Area of Science:

  • Immunogenetics
  • Cardiovascular Disease Epidemiology

Background:

  • Idiopathic dilated cardiomyopathy (IDC) is a complex condition potentially triggered by environmental factors in genetically susceptible individuals.
  • The role of specific human leukocyte antigen (HLA) alleles, such as HLA-DR3, in IDC risk remains unclear due to conflicting published data.

Purpose of the Study:

  • To conduct a meta-analysis to precisely evaluate the association between the HLA-DR3 antigen and the risk of developing IDC.
  • To provide a clearer understanding of the genetic susceptibility factors in IDC.

Main Methods:

  • A systematic literature search was performed on PUBMED and Embase databases up to June 2015.
  • Data from 19 case-control studies, encompassing 1378 IDC cases and 10383 controls, were analyzed.
  • Subgroup analyses were conducted based on myocardial biopsy status and ethnicity.

Main Results:

  • A significantly decreased frequency of the HLA-DR3 allele was observed in IDC patients compared to controls (OR=0.72, P=0.004).
  • This protective association was more pronounced in myocardial biopsy-confirmed IDC cases (OR=0.69, P=0.0003).
  • A borderline statistically significant decreased risk was noted among European populations (OR=0.76, P=0.05).

Conclusions:

  • The findings suggest that the presence of the HLA-DR3 antigen may confer a protective effect against the development of idiopathic dilated cardiomyopathy.
  • HLA-DR3 could be a significant genetic factor influencing susceptibility or resistance to IDC.

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