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Updated: Mar 23, 2026

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Behçet's Disease and Nervous System Involvement.

Murat Kürtüncü1, Erdem Tüzün2, Gulsen Akman-Demir3

  • 1Istanbul Faculty of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey.

Current Treatment Options in Neurology
|March 24, 2016
PubMed
Summary

Effective management of neuro-Behçet

Keywords:
Autoinflammatory disorderBehçet’s diseaseImmunosuppressionNeuro-Behçet’s diseaseTreatment

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Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Neuro-Behçet's disease requires distinct strategies for acute attacks and relapse prevention.
  • Corticosteroids are standard for acute neuroinflammatory episodes.

Purpose of the Study:

  • To outline current and emerging therapeutic approaches for neuro-Behçet's disease.
  • To discuss management strategies for both acute exacerbations and long-term disease control.

Main Methods:

  • Review of established treatment protocols for neuro-Behçet's disease.
  • Discussion of conventional immunosuppressants and advanced biologic therapies.

Main Results:

  • High-dose intravenous corticosteroids followed by oral steroids are used for acute attacks.
  • Oral immunosuppressants like azathioprine and mycophenolate are primary relapse prevention agents.
  • Refractory cases may benefit from cyclophosphamide, interferon alpha, or anti-TNF-α agents (infliximab, etanercept, adalimumab).

Conclusions:

  • Standard immunosuppressants are effective for relapse prevention in neuro-Behçet's disease.
  • Biologic agents targeting IL-1 and IL-6 pathways (tocilizumab, canakinumab, anakinra) show promise for refractory or progressive cases.